Involvement of Inducible Costimulator-B7

Murine Lupus Nephritis Homologous Protein Costimulatory Pathway Involvement of Inducible Costimulator-B7

Cutting edge: the related molecules CD28 and inducible costimulator deliver both unique and complementary signals required for optimal T cell activation.

Optimal T cell activation requires engagement of CD28 with its counterligands B7-1 and B7-2. Inducible costimulator (ICOS) is the third member of the CD28/CTLA4 family that binds a B7-like protein, B7RP-1. Administration of ICOS-Ig attenuates T cell expansion following superantigen (SAg) administration, but fails to regulate either peripheral deletion or anergy induction. ICOS-Ig, but not CTLA4...

Homologous Protein Costimulation by Blockade of Inducible Costimulator-B7 Amelioration of Collagen-Induced Arthritis

Functional significance of the interaction between inducible costimulator (ICOS) and its ligand (ICOSL)

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Expression and function of the inducible costimulator ligand B7-H2 in human airway smooth muscle cells.

BACKGROUND B7-H2 is a ligand for the inducible costimulator (ICOS). The aim of this study was to examine the expression and function of B7-H2 in human airway smooth muscle (ASM) cells and compare them with those of CD40 or OX40 ligand (OX40L). METHODS Expression of B7-H2, CD40 and OX40L in ASM cells and their respective counterparts in T cells was analyzed by RT-PCR or flow cytometry. The mod...